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FDG Avid Potts Spine-PET/CT

Case report: FDG Avid Osteolytic lesions in multifocal dorsolumbar vertebrae and sternum. Patient is 38 year old male, Myeloma was  ruled out and CT guided biopsy was negative for malignancy.  Finally in one of the biopsies, tubercular granulomas were noted. There are many case reports which have found while performing FDG PET/CT for oncologic workup, TB to be a common cancer mimic, producing uptake patterns that are indistinguishable from that of cancer.

The future: FDG-PET has a high sensitivity for infection and inflammation but poor specificity. One approach that may increase the diagnostic accuracy of PET for tuberculosis includes the combined use of F-18 FDG and C-11 acetate, as the latter accumulates in tumors but not in inflammatory lesion. Thus, C-11 acetate may help differentiate inflammation from neoplasms. 

Further reading & Reference: Indian J Radiol Imaging. 2008 May; 18(2): 141–147. Pictorial essay: PET/CT in tuberculosis. S Harkirat, SS Anana, LK Indrajit, and AK Dash
FDG Avid Potts Spine-PET/CT Reviewed by Sumer Sethi on Saturday, August 10, 2013 Rating: 5

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