Top Ad unit 728 × 90

Radiology News


‪Donepezil‬ PET-Notes

‪#‎Parkinson‬'s disease is associated with early parasympathetic dysfunction leading to constipation and gastroparesis. The positron emission tomography tracer 5-[(11)C]-methoxy-donepezil was recently validated for imaging acetylcholinesterase density in the brain and peripheral organs.

#Donepezil is a high-affinity ligand for ‪#‎acetylcholinesterase‬-the enzyme that catabolizes acetylcholine in cholinergic synapses. Decreases in (11)C-donepezil binding may, therefore, represent a marker of parasympathetic denervation of internal organs.
‪Donepezil‬ PET-Notes Reviewed by Sumer Sethi on Monday, March 16, 2015 Rating: 5

No comments:

All Rights Reserved by Sumer's Radiology Blog © 2014 - 2015
Powered By Blogger,

Contact Form


Email *

Message *

All contents copyrights with Sumer Sethi. Powered by Blogger.