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Manganese Based Alternative to Gadolinium: Journal Watch

The use of gadolinium-based contrast agents in MR images has become one of radiology’s most debated topic.  In a study published in Radiology, a manganese-based contrast agent, manganese-N-picolyl-N,N’,N’-trans-1,2-cyclohexenediaminetriacetate (Mn-PyC3A) is shown  enable contrast-enhanced MR angiography with comparable contrast enhancement to gadolinium-based agents and may overcome concerns regarding gadolinium-associated toxicity and retention.   Eric M. Gale et al compared contrast material–enhanced MR angiography  in baboons by using Mn-PyC3A and Gd-DTPA. 

Reference and Further Reading 
Manganese Based Alternative to Gadolinium: Journal Watch Reviewed by Sumer Sethi on Thursday, November 16, 2017 Rating: 5

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