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Fibrous Dysplasia: Radio-Path Correlation

Fibrous dysplasia is a mosaic disease resulting from post-zygotic activating mutations of the GNAS locus at 20q13.2-q13.3, which codes for the α subunit of the Gs G-coupled protein receptor. In bone, constitutive Gsα signaling results in impaired differentiation and proliferation of bone marrow stromal cellsProliferation of these cells causes replacement of normal bone and marrow with fibrous tissue. The bony trabeculae are abnormally thin and irregular, and often likened to Chinese characters

Fibrous Dysplasia: Radio-Path Correlation Reviewed by Sumer Sethi on Tuesday, December 13, 2016 Rating: 5

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