FTLD Dementia
Case Report: 57 yr old male executive with progressing dementia on MRI shows asymmetrical left anterior temporal/ hippocampal atrophy including parahippocampal gyrus with dilated temporal horn and subtle gliotic foci , possibly representing Semantic variant of primary progressive aphasia of FTLD Group in view of typical presentation.
![](https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEigLH6CWfMvcG0I4KJtsiaEzEYzZnvwhGZhHT8gOPm10M_91dOvy7TrRdActbracCe9ejds2V3YpBXgxdWk3nKtzutno23xJsbp3tLgl1LhHw2n_xYIV4qHVqZhMapx6ockrQt8ag/s640/blogger-image-98686894.jpg)
![](https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEj0k8T3SLPJ1HLvif85W3J9MEtWjW4w-g5tJTVyR9o6nLYUX21ZsklICJb1lcGg_ekgxxuG1GK8rYvNgAaqRcdrZrcgdMsyR1bK6_pXZCTT0uXvv0AomCEyEr0AEfTvOuPp1hQ8gg/s640/blogger-image--1414483632.jpg)
Teaching points by Dr MGK Murthy, Dr David and Technologist Mr Ram Murti
1.Imaging evaluation of dementias can be grouped in to
(a) Global cortical atrophy (GCA) (score of 0-3(called knife blade variety) depending on the quantum of volume loss)( In senile and other varieties more important)
(b)Medial Temporal Lobe atrophy (MTA) -Visual rating score of 0-4 (depending on choroid fissure/temporal horn and height of hippocampal loss)(Alzheimers disease more important)
(c)Koedam Score for parietal lobe atrophy (score of 0-3)((Senile more important)
(d) Fazekas Score (periventricular hyperintesntieis) (score of 0-3 depending on number and confluencing pattern)(senile &FTLD more important)
(e)Strategic infarcts (some areas vital for cognition) (Thalami/ Watershed zones/ parieto -temporal and temporo-occipital/ angular gyrus)( In Multiinfarct dementia variety more important)
2.Semantic variant of primary progressive aphasia or simply referred to as semantic dementia is a language variant of Fronto Temporal Lobe Dementias (previous Picks disease) (FTLD accounts for 5-10%of dementias)
3.clinically it displays (a)confrontation naming (b) single word comprehensions are decreased along with (c) impaired object knowledge (d) surface dyslexia / dysgraphia (e) spared repetition and speech production including motor /grammar speech
4. Early on, loss of temporal lobe function leads to language dysfunction (with speech maintained called Empty fluent speech) and later frontal variety gets added .
5.Alzheimers can be differentiated by no loss of memory for lifes memorable events (episodic memory)
FTLD Dementia
Reviewed by Sumer Sethi
on
Thursday, October 22, 2015
Rating:
![](https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEigLH6CWfMvcG0I4KJtsiaEzEYzZnvwhGZhHT8gOPm10M_91dOvy7TrRdActbracCe9ejds2V3YpBXgxdWk3nKtzutno23xJsbp3tLgl1LhHw2n_xYIV4qHVqZhMapx6ockrQt8ag/s72-c/blogger-image-98686894.jpg)
No comments:
Post a Comment